Going to college—in and of itself, sans context—isn't entirely remarkable. Literally thousands of people do it. But when you're the lead singer of a coffee-infused punk band in the early 1980s, and your down time en route to picking up your Ph.D in Biochemistry is spent at the intersection of extended adolescence and minute-long thrash-centric "nerdcore" people tend to notice.
And that's before we get to scribbled, iconic mascots. The Descendants Milo Goes To College is an exercise in differentiation: in what happens when we have to grow up, but do so defiantly. And, apparently, in two minutes or less.